The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors

Chembiochem. 2004 Nov 5;5(11):1575-9. doi: 10.1002/cbic.200400135.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / classification
  • Alkaloids / pharmacology
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / classification
  • Enzyme Inhibitors / pharmacology
  • Heterocyclic Compounds, 3-Ring / chemistry*
  • Heterocyclic Compounds, 3-Ring / classification
  • Heterocyclic Compounds, 3-Ring / pharmacology
  • Humans
  • Molecular Structure
  • Prodigiosin / chemistry*
  • Prodigiosin / classification
  • Prodigiosin / pharmacology
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases / antagonists & inhibitors*
  • Pyrroles / chemistry*
  • Pyrroles / classification
  • Pyrroles / pharmacology

Substances

  • Alkaloids
  • Enzyme Inhibitors
  • Heterocyclic Compounds, 3-Ring
  • Pyrroles
  • roseophilin
  • PTPN1 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases
  • Prodigiosin